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Authors
Abstract(s)
O presente relatório que foi realizado no âmbito da unidade curricular “Estágio” do
Mestrado Integrado em Ciências Farmacêuticas, encontra-se dividido em dois capítulos
que correspondem à vertente de Investigação e à vertente de Farmácia Comunitária,
respetivamente. No primeiro capítulo foram revistas e analisadas algumas das alterações
provocadas pela microgravidade nas propriedades cinéticas de variados fármacos. Até
muito recentemente os fármacos eram administrados numa estação espacial de forma
igual ao que acontece na Terra, mas começou a perceber-se que com as várias alterações
fisiológicas já bem estudadas em microgravidade, alguns fármacos comportam-se de
maneira diferente e por isso tem de ser administrados de outra forma e com mais
precaução, devido ao possível risco para a saúde dos tripulantes. Para sintetizar tanto as
alterações fisiológicas como as variações farmacocinéticas foi feita uma pesquisa
bibliográfica na base de dados Web of Science e procedeu-se à esquematização da
informação encontrada e à subsequente análise. Após a observação detalhada da
informação científica de vários fármacos usados pelos astronautas e comparando com a
literatura da área conclui-se que os modelos usados para simular a microgravidade
experienciada em condições de voo espacial, mimetizam as alterações físicas que os
humanos sofrem em microgravidade e percebeu-se que as alterações cinéticas dependem
de fármaco para fármaco ou entre classes farmacológicas, isto porque cada fármaco tem
a sua estrutura química e quando os processos de absorção, distribuição, metabolismo e
excreção do organismo são alterados a ação farmacológica desse fármaco pode também
ser alterada. Estas diferenças podem transformar-se num risco ou não para os
tripulantes de missões espaciais. Contudo ainda são necessários mais e melhores
estudos. O segundo capítulo consiste no relatório onde está documentado o conjunto de
atividades desenvolvidas durante o período de estágio na Farmácia Santa Ana, que
decorreu no período de 11 de setembro de 2023 a 2 de fevereiro de 2024, sob orientação
do Dr. Raúl Almeida. Neste capítulo são descritas todas as atividades realizadas ao longo
deste estágio, desde a organização e gestão da farmácia até às evoluções tecnológicas e
legislativas ocorridas na área de saúde, bem como a comunicação com o utente.
The present report, which was carried out as part of the “Internship” curricular unit of the Integrated Master's Degree in Pharmaceutical Sciences, is divided into two chapters that correspond to the research strand and the community pharmacy strand, respectively. The first chapter some changes caused by microgravity in the pharmacokinetics of various drugs were reviewed and analysed. Until very recently, drugs were administered on the space station in the same way as they are given on Earth, but it began to be realized that with the various physiological changes already well studied in microgravity, some drugs behave differently and therefore have to be administered in a different way and with more caution, due to the possible risk to crew members' health. To summarise both the physiological changes and the pharmacokinetic variations, a bibliographic search was carried out in the Web of Science database, and the information found was schematized and subsequently analysed. After detailed observation of the scientific information on various drugs used by astronauts and comparing with the literature in the field, it is concluded that the models used to simulate the microgravity experienced in space flight conditions, mimic the physical alterations that humans undergo in microgravity and it was noted that the pharmacokinetic alterations depend from drug to drug or between pharmacological classes, because each drug has its own mechanism of action and chemical structure and when the absorption, distribution, metabolism and excretion of the drug from the body is altered, the behaviour of that drug is also altered. These differences may or may not become a risk to crew members on space missions. However, more and better studies are still needed. The second chapter consists of a report documenting all the activities carried out during my internship at Farmácia Santa Ana, which took place from September 11, 2023 to February 2, 2024, under the guidance of Dr Raúl Almeida. This chapter describes all the activities carried out during this internship, from the organisation and management of the pharmacy to technological and legislative developments in the health sector, as well as communication with the patient.
The present report, which was carried out as part of the “Internship” curricular unit of the Integrated Master's Degree in Pharmaceutical Sciences, is divided into two chapters that correspond to the research strand and the community pharmacy strand, respectively. The first chapter some changes caused by microgravity in the pharmacokinetics of various drugs were reviewed and analysed. Until very recently, drugs were administered on the space station in the same way as they are given on Earth, but it began to be realized that with the various physiological changes already well studied in microgravity, some drugs behave differently and therefore have to be administered in a different way and with more caution, due to the possible risk to crew members' health. To summarise both the physiological changes and the pharmacokinetic variations, a bibliographic search was carried out in the Web of Science database, and the information found was schematized and subsequently analysed. After detailed observation of the scientific information on various drugs used by astronauts and comparing with the literature in the field, it is concluded that the models used to simulate the microgravity experienced in space flight conditions, mimic the physical alterations that humans undergo in microgravity and it was noted that the pharmacokinetic alterations depend from drug to drug or between pharmacological classes, because each drug has its own mechanism of action and chemical structure and when the absorption, distribution, metabolism and excretion of the drug from the body is altered, the behaviour of that drug is also altered. These differences may or may not become a risk to crew members on space missions. However, more and better studies are still needed. The second chapter consists of a report documenting all the activities carried out during my internship at Farmácia Santa Ana, which took place from September 11, 2023 to February 2, 2024, under the guidance of Dr Raúl Almeida. This chapter describes all the activities carried out during this internship, from the organisation and management of the pharmacy to technological and legislative developments in the health sector, as well as communication with the patient.
Description
Keywords
Farmácia Comunitária Farmacocinética Microgravidade Modelos Animais Modelos Humanos Voo Espacial