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Abstract(s)
A Diabetes Mellitus (DM) é uma doença crónica e um importante problema de saúde pública, uma das quatro doenças não-transmissíveis prioritárias (DNT’s) mencionadas pela Organização Mundial de Saúde, e cuja sua prevalência tem aumentado drasticamente ao longo do tempo.
A hiperglicemia, um efeito comum da diabetes não controlada, pode, ao longo do tempo, levar a importantes complicações. Estas podem ser caracterizadas por problemas cardiovasculares, nefropatias, neuropatias e problemas oculares.
Como consequência, veio o interesse de estudar a influência da diabetes numa das estruturas do olho, a córnea, na qual foi observada a presença de sinais e características significantes relacionadas com a diabetes. O objetivo deste estudo consistiu em analisar alterações na espessura e densidade ótica corneal em pacientes com Diabetes Mellitus tipo 2. Paralelamente, foi realizada uma análise da relação destas duas variáveis com fatores de risco tais como, o sexo, tempo de diagnóstico da DM, Hemoglobina Glicada A1c (HbA1c), Índice de massa corporal (IMC) e o colesterol total. Não foram encontradas diferenças estatisticamente significativas na espessura da córnea de pacientes diabéticos e não-diabéticos. No entanto, foi verificado que a espessura da membrana de Bowman é significativamente mais baixa em pacientes com diabetes.
O mesmo acontece para os valores de densidade, em que não foram encontradas diferenças estatisticamente significativas, no que se refere à densidade por camada. Contrariamente ao que verifica quando é analisada a densidade radial, em que são encontrados resultados significativos em todas as camadas, excetuando na camada posterior.
Em suma, foram encontradas algumas alterações associadas à presença da Diabetes Mellitus nas variáveis estudadas.
Diabetes Mellitus (DM) is a chronic disease and an important public health problem, one of the four priority noncommunicable diseases (NCDs) mentioned by the World Health Organization, whose prevalence has increased dramatically over time. Hyperglycemia, a common effect of uncontrolled diabetes, can, over time, lead to important complications. These can be characterized by cardiovascular problems, nephropathies, neuropathies and eye problems. Consequently, the interest came to study the influence of diabetes in one of the structures of the eye, the cornea, in which significant signs and characteristics related to diabetes were observed. The objective of this study was to analyze changes in thickness and corneal density in patients with type 2 diabetes mellitus. In parallel, an analysis was made of the relationship between these two variables with risk factors such as gender, time of diagnosis of DM, glycated hemoglobin A1c (HbA1c), body mass index (BMI), and total cholesterol. No statistically significant differences were found in the thickness of diabetic and non-diabetic patients. However, it has been found that Bowman's membrane thickness is significantly lower in patients with diabetes. The same is true for density values, where no statistically significant differences were found for density per layer. Contrary to what is verified when the radial density is analyzed, in which significant results are found in all the layers, except in the posterior layer. In summary, we found some changes associated with the presence of Diabetes Mellitus in the studied variables.
Diabetes Mellitus (DM) is a chronic disease and an important public health problem, one of the four priority noncommunicable diseases (NCDs) mentioned by the World Health Organization, whose prevalence has increased dramatically over time. Hyperglycemia, a common effect of uncontrolled diabetes, can, over time, lead to important complications. These can be characterized by cardiovascular problems, nephropathies, neuropathies and eye problems. Consequently, the interest came to study the influence of diabetes in one of the structures of the eye, the cornea, in which significant signs and characteristics related to diabetes were observed. The objective of this study was to analyze changes in thickness and corneal density in patients with type 2 diabetes mellitus. In parallel, an analysis was made of the relationship between these two variables with risk factors such as gender, time of diagnosis of DM, glycated hemoglobin A1c (HbA1c), body mass index (BMI), and total cholesterol. No statistically significant differences were found in the thickness of diabetic and non-diabetic patients. However, it has been found that Bowman's membrane thickness is significantly lower in patients with diabetes. The same is true for density values, where no statistically significant differences were found for density per layer. Contrary to what is verified when the radial density is analyzed, in which significant results are found in all the layers, except in the posterior layer. In summary, we found some changes associated with the presence of Diabetes Mellitus in the studied variables.
Description
Keywords
Densitometria Corneal Diabetes Mellitus Espessura Corneal Tomografia de Coerência Ótica Tomografia de Scheimpflug