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Abstract(s)
O presente relatório destina-se à exposição das atividades realizadas no âmbito da
Unidade Curricular “Estágio” do Mestrado Integrado em Ciências Farmacêuticas da
Universidade da Beira Interior e encontra-se dividido em dois capítulos.
O primeiro capítulo diz respeito ao projeto de investigação intitulado “Desenvolvimento
de microemulsões de fenitoína e fosfenitoína” desenvolvido no Centro de Investigação
em Ciências da Saúde da Universidade da Beira Interior. A via nasal para o
direcionamento cerebral de fármacos tem vindo a ser muito estudada por permitir a
entrega de moléculas de uma forma rápida e permitir contornar algumas limitações das
preparações orais e injetáveis. O objetivo deste trabalho foi formular uma microemulsão
de fenitoína para administração nasal, procurando maximizar a dosagem deste fármaco.
Foram exploradas diversas fórmulas partindo de excipientes escolhidos com base em
dados bibliográficos e experimentais. Depois de feita a seleção, as formulações finais
foram caracterizadas de acordo com o seu diâmetro hidrodinâmico, homogeneidade da
formulação, viscosidade e osmolalidade. Apesar de se terem alcançado algumas
formulações com boas características não se conseguiu maior dosagem de fenitoína do
que em formulações anteriores.
O segundo capítulo é referente ao estágio em Farmácia Comunitária, realizado na
Farmácia Sant’Ana, na Covilhã, onde pude acompanhar e participar nas diversas etapas
do circuito do medicamento, nomeadamente o aprovisionamento, receção de
encomendas, armazenamento, aconselhamento e dispensa de medicamentos e produtos
de saúde e bem-estar.
This report is intended to present the activities carried out within the scope of the “Internship” course of the Integrated Master’s degree in Pharmaceutical Sciences of University of Beira Interior, and it is divided into two chapters. The first chapter concerns the research project entitled “Development of phenytoin and fosphenytoin microemulsions”, developed at the Health Sciences Research Center of University of Beira Interior. The nasal route has been studied for brain targeting, allowing a faster delivery of molecules and to overcome some limitations of oral and injectable preparations. The objective of this work was to formulate a microemulsion of phenytoin for nasal administration, seeking to maximize the strength of this drug. Several formulations were explored, with a composition based on bibliographic and experimental data. After composition selection, the final formulations were characterized in what concerned their hydrodynamic diameter, homogeneity, viscosity and osmolality. Although some formulations with good characteristics were developed successfully, the objective of maximizing phenytoin drug strength (compared to previous formulations) was not reached. The second chapter refers to the internship in Community Pharmacy, held at the Pharmacy Sant'Ana, in Covilhã, where I was able to accompany and participate in the various stages of the medicine circuit, namely the supply, reception, storage, advising and dispensing of medicines and other health products.
This report is intended to present the activities carried out within the scope of the “Internship” course of the Integrated Master’s degree in Pharmaceutical Sciences of University of Beira Interior, and it is divided into two chapters. The first chapter concerns the research project entitled “Development of phenytoin and fosphenytoin microemulsions”, developed at the Health Sciences Research Center of University of Beira Interior. The nasal route has been studied for brain targeting, allowing a faster delivery of molecules and to overcome some limitations of oral and injectable preparations. The objective of this work was to formulate a microemulsion of phenytoin for nasal administration, seeking to maximize the strength of this drug. Several formulations were explored, with a composition based on bibliographic and experimental data. After composition selection, the final formulations were characterized in what concerned their hydrodynamic diameter, homogeneity, viscosity and osmolality. Although some formulations with good characteristics were developed successfully, the objective of maximizing phenytoin drug strength (compared to previous formulations) was not reached. The second chapter refers to the internship in Community Pharmacy, held at the Pharmacy Sant'Ana, in Covilhã, where I was able to accompany and participate in the various stages of the medicine circuit, namely the supply, reception, storage, advising and dispensing of medicines and other health products.
Description
Keywords
Administração Nasal Direcionamento Cerebral Farmácia Comunitária Fenitoína Microemulsões