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Abstract(s)
Introdução: A Síndrome de Sheehan consiste na necrose do lobo anterior da glândula
hipofisária consequente a, habitualmente, hemorragias significativas pós-parto,
hipovolemia e choque, que gera pan-hipopituitarismo. Tendo em conta a complexidade
e a diversidade das manifestações clínicas da Síndrome de Sheehan, as manifestações
psiquiátricas em associação com esta patologia são pouco descritas na literatura, assim
como é pouco esclarecido este mecanismo de etiopatogenia.
Objetivos: Esta dissertação visa identificar o estado de conhecimento relativo à
relação da sintomatologia psiquiátrica com a Síndrome de Sheehan, quer seja esta uma
relação que se estabelece como comorbilidade, etiologia ou complicação do tratamento
da patologia endócrina.
Métodos: Para a elaboração desta dissertação, procedeu-se a uma pesquisa
bibliográfica de artigos científicos nas plataformas PubMed e Scopus. Utilizaram-se as
seguintes palavras-chaves: sheehan syndrome (title) AND psychosis (all fields) AND
mental disorder (all fields) AND psychiatric symptoms (all fields).
Resultados: Foram analisados 15 artigos que abordavam a relação entre Síndrome de
Sheehan e a sintomatologia psiquiátrica. Verificou-se que os sintomas psiquiátricos
podem ser forma de apresentação etiologicamente relacionada ou complicação da
Síndrome de Sheehan. Ademais, como complicação da terapêutica da patologia
endócrina, podem ocorrer manifestações psiquiátricas. Além disso, também foi
verificado um maior atraso diagnóstico e um maior nível de parâmetros inflamatórios
em pacientes com esta associação. Por fim, as associações encontradas foram entre
Síndrome de Sheehan e psicose, delírio e depressão major.
Conclusão: Os estudos analisados permitem observar uma relação positiva entre a
existência da Síndrome de Sheehan e a ocorrência de sintomatologia psiquiátrica,
verificando que esta relação pode ter carizes diferentes. No entanto, a etiopatogenia da
associação é ainda pouco compreendida. Por outro lado, deve ser realizada uma maior
investigação nesta temática, a fim de promover um maior conhecimento dos
mecanismos que levam à mesma, assim como estabelecer importantes guidelines para
a gestão de Síndrome de Sheehan e manifestações psiquiátricas.
Introduction: Sheehan's Syndrome consists of necrosis of the anterior lobe of the pituitary gland resulting, usually, from severe postpartum hemorrhages, hypovolemia and shock, which generate panhypopituitarism. Taking into account the complexity and diversity of the clinical manifestations of Sheehan's Syndrome, the psychiatric manifestations associated with it are little described in the literature, just as the etiopathological mechanism is little clarified. Aims: This dissertation aims to identify the state of knowledge regarding the relationship between psychiatric symptoms and Sheehan's Syndrome, whether this is a relationship that is established as comorbidity, etiology or treatment complication of the endocrine disease. Methods: To prepare this dissertation, a bibliographical research of scientific articles was carried out on the PubMed and Scopus platforms. The following keywords were used: sheehan syndrome (title) AND psychosis (all fields) AND mental disorder (all fields) AND psychiatric symptoms (all fields). Results: This work analyzed 15 articles that addressed the relationship between Sheehan Syndrome and psychiatric symptoms. It was found that psychiatric symptoms may be an etiologically related presentation or complication of Sheehan Syndrome. Furthermore, as a complication of endocrine pathology therapy, psychiatric manifestations may occur. Furthermore, a greater diagnostic delay and a higher level of inflammatory parameters were also observed in patients with this association. Finally, the associations found were between Sheehan Syndrome, psychosis, delirium and major depression. Conclusion: The studies analyzed conclude positively about the existence of a relationship between Sheehan's Syndrome and the occurrence of psychiatric symptoms, verifying that this relationship can have different natures. However, the etiopathology of the association is still poorly understood. On the other hand, greater research should be carried out on this topic, in order to promote greater knowledge of the mechanisms that lead to it, as well as to establish important guidelines for the management of Sheehan Syndrome and psychiatric manifestations.
Introduction: Sheehan's Syndrome consists of necrosis of the anterior lobe of the pituitary gland resulting, usually, from severe postpartum hemorrhages, hypovolemia and shock, which generate panhypopituitarism. Taking into account the complexity and diversity of the clinical manifestations of Sheehan's Syndrome, the psychiatric manifestations associated with it are little described in the literature, just as the etiopathological mechanism is little clarified. Aims: This dissertation aims to identify the state of knowledge regarding the relationship between psychiatric symptoms and Sheehan's Syndrome, whether this is a relationship that is established as comorbidity, etiology or treatment complication of the endocrine disease. Methods: To prepare this dissertation, a bibliographical research of scientific articles was carried out on the PubMed and Scopus platforms. The following keywords were used: sheehan syndrome (title) AND psychosis (all fields) AND mental disorder (all fields) AND psychiatric symptoms (all fields). Results: This work analyzed 15 articles that addressed the relationship between Sheehan Syndrome and psychiatric symptoms. It was found that psychiatric symptoms may be an etiologically related presentation or complication of Sheehan Syndrome. Furthermore, as a complication of endocrine pathology therapy, psychiatric manifestations may occur. Furthermore, a greater diagnostic delay and a higher level of inflammatory parameters were also observed in patients with this association. Finally, the associations found were between Sheehan Syndrome, psychosis, delirium and major depression. Conclusion: The studies analyzed conclude positively about the existence of a relationship between Sheehan's Syndrome and the occurrence of psychiatric symptoms, verifying that this relationship can have different natures. However, the etiopathology of the association is still poorly understood. On the other hand, greater research should be carried out on this topic, in order to promote greater knowledge of the mechanisms that lead to it, as well as to establish important guidelines for the management of Sheehan Syndrome and psychiatric manifestations.
Description
Keywords
Delírio Depressão Major Psicose Síndrome de Sheehan Sintomatologia Psiquiátrica