| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 788.08 KB | Adobe PDF |
Authors
Abstract(s)
ntrodução: A estimulação magnética repetitiva (EMr) e a sua variante theta
burst stimulation (TBS) são técnicas que apareceram no contexto da insuficiência de
terapêuticas médicas alternativas para patologias do foro psiquiátrico, onde a sua
aplicação tem sido útil. Apesar de cada vez mais estudada, o resultado fisiológico do
processo não está totalmente esclarecido a nível central e/ou periférico.
Objetivo: O objetivo deste estudo foi tentar perceber se uma sessão de TBS
produz alterações na função nervosa do nervo periférico em indivíduos jovens
saudáveis, avaliada por estudos eletroneurográficos.
Metodologia de Investigação: Este estudo incluiu um total de 25
voluntários, 15 submetidos a TBS contínua excitatória (iTBS) do nervo mediano e 10
pertencendo ao grupo de controlo não submetido a TBS. Foram realizadas avaliações
eletroneurográficas do nervo mediano antes e após a estimulação, avaliando 9 variáveis
divididas entre a resposta motora, sensitiva e autonómica.
Resultados: A iTBS sobre o nervo periférico provocou um aumento
estatisticamente significativo da latência das respostas F (p=0,001) e da resposta
simpática da pele (p=0,025), assim como a diminuição da velocidade de condução
sensitiva (p=0,023). Apesar disto, a comparação entre os grupos de intervenção e
controlo não apresentou qualquer diferença estatisticamente significativa. Nenhuma
alteração foi encontrada ao nível das amplitudes
Conclusão: Neste estudo concluiu-se que a iTBS do nervo periférico parece ter
provocado uma lentificação da função nervosa. Contudo, verificamos ausência de
diferenças na comparação com o grupo de controlo e diminuída magnitude das
variações observadas em termos absolutos e clínicos. Poderia ser vantajoso um estudo
com uma maior amostra de forma a obter resultados mais robustos, para melhor
entender os mecanismos subjacentes a esta técnica a nível periférico.
Introduction: Repetitive magnetic stimulation and its variant theta burst stimulations (TBS) are techniques that appeared in the context of the insufficiency of alternative medical therapies for psychiatric conditions, where its application has been useful. Despite being increasingly studied, the physiological outcome of the process is not entirely known at a central and peripheral level. Objective: The objective of this study was to try to understand if a TBS session produces changes in peripheral nerve function in healthy young subjects, assessed by electroneurographic studies. Investigation Methodology: This study included a total of 25 volunteers, 15 undergoing continuous excitatory TBS of the median nerve and 10 belonging to the control group, not submitted to TBS. Electroneurographic assessments of the median nerve were performed before and after stimulation, evaluating 9 variables divided between the motor, sensory and autonomic responses. Results: Peripheral nerve iTBS caused a statistically significant increase in the latency of the F response (p=0,001) and sympathetic skin response (p=0,025), as well as a decrease in sensory conduction velocity (p=0,023). Despite this, the comparison between the intervention and control groups showed no statistical difference. No changes were found in terms of amplitudes. Conclusion: In this study we concluded that iTBS of the peripheral nerve seems to have caused a slowing of nerve function. However, we found no differences in the comparison with the control group and a reduced magnitude of the variations observed in absolute and clinical terms. A study with a larger sample would be advantageous to obtain more robust results, to better understand the mechanisms underlying this technique at a peripheral level.
Introduction: Repetitive magnetic stimulation and its variant theta burst stimulations (TBS) are techniques that appeared in the context of the insufficiency of alternative medical therapies for psychiatric conditions, where its application has been useful. Despite being increasingly studied, the physiological outcome of the process is not entirely known at a central and peripheral level. Objective: The objective of this study was to try to understand if a TBS session produces changes in peripheral nerve function in healthy young subjects, assessed by electroneurographic studies. Investigation Methodology: This study included a total of 25 volunteers, 15 undergoing continuous excitatory TBS of the median nerve and 10 belonging to the control group, not submitted to TBS. Electroneurographic assessments of the median nerve were performed before and after stimulation, evaluating 9 variables divided between the motor, sensory and autonomic responses. Results: Peripheral nerve iTBS caused a statistically significant increase in the latency of the F response (p=0,001) and sympathetic skin response (p=0,025), as well as a decrease in sensory conduction velocity (p=0,023). Despite this, the comparison between the intervention and control groups showed no statistical difference. No changes were found in terms of amplitudes. Conclusion: In this study we concluded that iTBS of the peripheral nerve seems to have caused a slowing of nerve function. However, we found no differences in the comparison with the control group and a reduced magnitude of the variations observed in absolute and clinical terms. A study with a larger sample would be advantageous to obtain more robust results, to better understand the mechanisms underlying this technique at a peripheral level.
Description
Keywords
Condução Nervosa Estimulação Magnética Jovens Saudáveis Nervo Periférico Potencial de Ação