Publication
Action of Curcumin on Glioblastoma Growth: A Systematic Review with Meta-Analysis of Animal Model Studies
| dc.contributor.author | Luís, Ângelo | |
| dc.contributor.author | Amaral, Leonor | |
| dc.contributor.author | Domingues, F.C. | |
| dc.contributor.author | Pereira, L. | |
| dc.contributor.author | Cascalheira, José | |
| dc.date.accessioned | 2024-06-17T09:01:07Z | |
| dc.date.available | 2024-06-17T09:01:07Z | |
| dc.date.issued | 2024-01-24 | |
| dc.description.abstract | Gliomas are aggressive brain tumors with poor prognosis even after surgical removal and radio-chemotherapy, stressing the urgency to find alternative therapies. Several preclinical studies evaluating the anticancer effect of curcumin in animal models of glioma are reported, but a systematic review with meta-analysis of these studies, considering the different experimental conditions used, has not been made up to this date. A search in different databases (Pubmed, Web of Science, Scopus, and SciELO) following the PRISMA statement was conducted during November 2023 to systematically identify articles assessing the effect of curcumin in murine xenograft models of glioma and identified 15 articles, which were subdivided into 24 studies. Tumor volume before and after treatment with curcumin or vehicle was extracted and the efficacy of curcumin was evaluated by performing a random effects meta-analysis of the data. Publication bias and the impact of different experimental conditions on curcumin efficacy were assessed. Treatment with curcumin decreased tumor volume. Comparing curcumin with control groups, the overall weighted standardized difference in means was −2.079 (95% CI: −2.816 to −1.341; p-value < 0.001). The curcumin effect was observed for different animal models, types of glioma cells, administration routes, and curcumin formulations. Publication bias was identified but does not invalidate curcumin’s effectiveness. The findings suggest the potential therapeutic efficacy of curcumin against glioma. | pt_PT |
| dc.description.sponsorship | Foundation for Science and Technology (FCT); CENTRO 2020 and LISBOA 2020 (POCI-01-0145-FEDER-016822) | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.3390/biomedicines12020268 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.6/14433 | |
| dc.language.iso | eng | pt_PT |
| dc.relation | Health Sciences Research Centre | |
| dc.relation | Health Sciences Research Centre | |
| dc.relation | Not Available | |
| dc.relation | Relationship between adenosine and chromosomal instability: a new perspective to understand the oncogenic mechanism in glioblastoma | |
| dc.relation | Center of Mathematics and Applications of University of Beira Interior | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Curcumin | pt_PT |
| dc.subject | Glioma | pt_PT |
| dc.subject | Glioblastoma | pt_PT |
| dc.subject | Animal model | pt_PT |
| dc.subject | Systematic review | pt_PT |
| dc.subject | Meta-analysis | pt_PT |
| dc.title | Action of Curcumin on Glioblastoma Growth: A Systematic Review with Meta-Analysis of Animal Model Studies | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Health Sciences Research Centre | |
| oaire.awardTitle | Health Sciences Research Centre | |
| oaire.awardTitle | Not Available | |
| oaire.awardTitle | Relationship between adenosine and chromosomal instability: a new perspective to understand the oncogenic mechanism in glioblastoma | |
| oaire.awardTitle | Center of Mathematics and Applications of University of Beira Interior | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/DL 57%2F2016/DL 57%2F2016%2FCP1354%2FCT0010/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/Projetos de Investigação Científica e Desenvolvimento Tecnológico - 2014 (P2020)/PTDC%2FBIM-ONC%2F7121%2F2014/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00212%2F2020/PT | |
| oaire.citation.issue | 2 | pt_PT |
| oaire.citation.startPage | 268 | pt_PT |
| oaire.citation.title | Biomedicines | pt_PT |
| oaire.citation.volume | 12 | pt_PT |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | DL 57/2016 | |
| oaire.fundingStream | Projetos de Investigação Científica e Desenvolvimento Tecnológico - 2014 (P2020) | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| person.familyName | Santos Luís | |
| person.familyName | Domingues | |
| person.familyName | Pereira | |
| person.familyName | da Silva Cascalheira | |
| person.givenName | Ângelo Filipe | |
| person.givenName | Fernanda | |
| person.givenName | Luísa | |
| person.givenName | José Francisco | |
| person.identifier.ciencia-id | 3D14-798B-65D3 | |
| person.identifier.ciencia-id | 6514-0498-3E8F | |
| person.identifier.ciencia-id | 4F15-1868-D001 | |
| person.identifier.ciencia-id | B219-078D-FD06 | |
| person.identifier.orcid | 0000-0003-0712-6522 | |
| person.identifier.orcid | 0000-0002-9540-0853 | |
| person.identifier.orcid | 0000-0002-9068-4607 | |
| person.identifier.orcid | 0000-0002-5315-3866 | |
| person.identifier.rid | N-7295-2013 | |
| person.identifier.scopus-author-id | 10139481400 | |
| person.identifier.scopus-author-id | 10839238300 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | a2d7c872-99db-41e1-9bc9-82c2d47b4661 | |
| relation.isAuthorOfPublication | 8d5fe6e2-21af-4557-9c46-84103254a18a | |
| relation.isAuthorOfPublication | 604e508e-9f4e-4950-b2a4-1b06c7192afe | |
| relation.isAuthorOfPublication | c2e80b79-19f9-4175-94bf-5751fad1b460 | |
| relation.isAuthorOfPublication.latestForDiscovery | c2e80b79-19f9-4175-94bf-5751fad1b460 | |
| relation.isProjectOfPublication | c7cee677-067c-47b2-ab19-b2dd5b0fda9d | |
| relation.isProjectOfPublication | a4dfaeb8-2685-4a99-ba26-acc4e4a3d7c5 | |
| relation.isProjectOfPublication | e4a98845-fa46-4626-b118-1ba89fd7067f | |
| relation.isProjectOfPublication | 2a0dfb30-ac47-4d36-b5d6-0091eff19149 | |
| relation.isProjectOfPublication | 8ba4cb1c-bd74-44b8-bc32-20b90c6c920d | |
| relation.isProjectOfPublication.latestForDiscovery | 8ba4cb1c-bd74-44b8-bc32-20b90c6c920d |