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Estudo da atividade antimicrobiana do extrato de Sorbus aucuparia contra Staphylococcus aureus
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O presente relatório, elaborado no âmbito da Unidade Curricular “Estágio” do Mestrado
Integrado em Ciências Farmacêuticas da Universidade da Beira Interior, organiza-se em
dois capítulos que descrevem a experiência profissional adquirida nas áreas de
Investigação e de Farmácia Comunitária.
O primeiro capítulo descreve o projeto de investigação desenvolvido no RISE Health com
o objetivo de estudar a atividade antibacteriana do extrato de Sorbus aucuparia, colhida
na região da Serra da Estrela, contra diferentes estirpes de Staphylococcus aureus.
O aumento dos valores de resistência antimicrobiana associada à lacuna preocupante no
desenvolvimento de novos antibióticos representa um desafio significativo para a saúde
pública. Este facto torna cada vez mais relevante a adoção de estratégias integradas de
prevenção, vigilância e utilização racional de antibióticos e a procura por novas fontes
terapêuticas. Espécies vegetais como Sorbus aucuparia têm sido estudadas pelo seu
potencial antimicrobiano, devido à sua composição química rica em compostos
bioativos. Este estudo teve como objetivo avaliar a atividade antimicrobiana do extrato
de S. aucuparia, colhida na região da Serra da Estrela, contra diferentes estirpes de
Staphylococcus aureus, incluindo MRSA. O extrato foi preparado a partir de folhas e
caules de S. aucuparia e testado contra estirpes previamente identificadas. A atividade
antimicrobiana foi avaliada através do teste de difusão em disco e da determinação da
concentração mínima inibitória. O extrato demonstrou baixa atividade antimicrobiana
contra as estirpes testadas, no entanto, este não é totalmente desprovido de compostos
bioativos. Para além disso também foi possível concluir que a concentração desses
compostos bioativos no extrato está dependente de múltiplos fatores.
O segundo capítulo descreve a experiência profissional desenvolvida na área da farmácia
comunitária, realizada na Farmácia São Cosme, na Covilhã, entre fevereiro e junho de
2025. Neste capítulo são descritos os conhecimentos adquiridos e as diversas atividades
executadas ao longo do estágio curricular.
The present report, prepared within the scope of the curricular unit “Internship” of the Integrated Master’s Degree in Pharmaceutical Sciences at the University of Beira Interior, is organised into two chapters that describe the professional experience acquired in the areas of Research and Community Pharmacy. The first chapter describes the research project developed at RISE Health, with the objective of studying the antibacterial activity of Sorbus aucuparia extract, harvested in the Serra da Estrela region, against different strains of Staphylococcus aureus. The increasing levels of antimicrobial resistance, combined with the worrying gap in the development of new antibiotics, represent a significant public health challenge. This situation highlights the growing importance of adopting integrated strategies for prevention, surveillance, and the rational use of antibiotics, as well as the search for new therapeutic sources. Plant species such as Sorbus aucuparia have been investigated for their antimicrobial potential due to their chemically diverse composition rich in bioactive compounds. This study aimed to evaluate the antimicrobial activity of S. aucuparia extract, collected in the Serra da Estrela region, against different Staphylococcus aureus strains, including MRSA. The extract was prepared from S. aucuparia leaves and stems and tested against previously identified strains. Antimicrobial activity was assessed using the disk diffusion method and by determining the minimum inhibitory concentration (MIC). Although the extract exhibited relatively low antimicrobial activity against the tested strains, it was not entirely devoid of bioactive compounds. Moreover, the concentration of these bioactive constituents in the extract was found to depend on multiple factors. The second chapter describes the professional experience developed in the field of community pharmacy, carried out at Farmácia São Cosme, in Covilhã, between February and June 2025. This chapter outlines the knowledge acquired and the various activities performed throughout the curricular internship.
The present report, prepared within the scope of the curricular unit “Internship” of the Integrated Master’s Degree in Pharmaceutical Sciences at the University of Beira Interior, is organised into two chapters that describe the professional experience acquired in the areas of Research and Community Pharmacy. The first chapter describes the research project developed at RISE Health, with the objective of studying the antibacterial activity of Sorbus aucuparia extract, harvested in the Serra da Estrela region, against different strains of Staphylococcus aureus. The increasing levels of antimicrobial resistance, combined with the worrying gap in the development of new antibiotics, represent a significant public health challenge. This situation highlights the growing importance of adopting integrated strategies for prevention, surveillance, and the rational use of antibiotics, as well as the search for new therapeutic sources. Plant species such as Sorbus aucuparia have been investigated for their antimicrobial potential due to their chemically diverse composition rich in bioactive compounds. This study aimed to evaluate the antimicrobial activity of S. aucuparia extract, collected in the Serra da Estrela region, against different Staphylococcus aureus strains, including MRSA. The extract was prepared from S. aucuparia leaves and stems and tested against previously identified strains. Antimicrobial activity was assessed using the disk diffusion method and by determining the minimum inhibitory concentration (MIC). Although the extract exhibited relatively low antimicrobial activity against the tested strains, it was not entirely devoid of bioactive compounds. Moreover, the concentration of these bioactive constituents in the extract was found to depend on multiple factors. The second chapter describes the professional experience developed in the field of community pharmacy, carried out at Farmácia São Cosme, in Covilhã, between February and June 2025. This chapter outlines the knowledge acquired and the various activities performed throughout the curricular internship.
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Palavras-chave
Atividade Antimicrobiana Extrato Etanólico Farmácia Comunitária Sorbus Aucuparia Staphylococcus
Aureus