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Advisor(s)
Abstract(s)
Nos dias de hoje já existe bastante informação que corrobora a hipótese do ácido acetilsalicílico mais conhecido como aspirina poder ter uma acção efectiva não só, na prevenção, bem como no tratamento do cancro colo-rectal (CCR).
Um conjunto de estudos randomizados e controlados de fase III está a decorrer no sentido de avaliar e aprofundar o conhecimento sobre o possível papel do ácido acetilsalicílico na prevenção e tratamento deste tipo de cancro.
Apesar de na maioria dos casos ser bem tolerado, o ácido acetilsalicílico apresenta alguns efeitos adversos que precisam de ser tidos em consideração como é o caso da dispepsia e da hemorragia. Deste modo, será importante aprofundar o debate sobre as vantagens e os riscos do possível uso do medicamento nos casos de cancro.
Nesta revisão pretende-se reunir o conhecimento existente que sugere um papel do ácido acetilsalicílico na prevenção e tratamento do CCR. Define-se igualmente como objectivo uma breve discussão sobre a existência de potenciais biomarcadores que auxiliem na avaliação da resposta ao ácido acetilsalicílico. Para finalizar, tenciona-se fazer uma reflexão sobre as vantagens e as desvantagens do uso do medicamento em questão no contexto do cancro.
Nowadays, there is a lot of information that supports the hypothesis that acetylsalicylic acid better known as aspirin can have an effective action not only in prevention but also in the treatment of colorectal cancer (CRC). A set of randomized, controlled phase III studies is underway to evaluate and deepen the potential role of acetylsalicylic acid in the prevention and treatment of this type of cancer. Although in most cases it is well tolerated, acetylsalicylic acid has some adverse effects that need to be taken into account such as dyspepsia and bleeding. In this way, it will be important to deepen the debate on the advantages and risks of the possible use of the drug in cancer cases. In this review we intend to gather the existing knowledge that suggests a role of acetylsalicylic acid in the prevention and treatment of CRC. A brief discussion on the existence of potential biomarkers that assist in assessing the response to acetylsalicylic acid is also an objective. Finally, it is intended to reflect on the advantages and disadvantages of using the drug in question in the context of cancer.
Nowadays, there is a lot of information that supports the hypothesis that acetylsalicylic acid better known as aspirin can have an effective action not only in prevention but also in the treatment of colorectal cancer (CRC). A set of randomized, controlled phase III studies is underway to evaluate and deepen the potential role of acetylsalicylic acid in the prevention and treatment of this type of cancer. Although in most cases it is well tolerated, acetylsalicylic acid has some adverse effects that need to be taken into account such as dyspepsia and bleeding. In this way, it will be important to deepen the debate on the advantages and risks of the possible use of the drug in cancer cases. In this review we intend to gather the existing knowledge that suggests a role of acetylsalicylic acid in the prevention and treatment of CRC. A brief discussion on the existence of potential biomarkers that assist in assessing the response to acetylsalicylic acid is also an objective. Finally, it is intended to reflect on the advantages and disadvantages of using the drug in question in the context of cancer.
Description
Keywords
Ácido Acetilsalicílico Biomarcadores Cancro Colo-Rectal Inflamação Quimioprevenção