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Abstract(s)
Introdução: A Síndrome de Sjögren primária é uma doença imunomediada, de caráter
crónico e evolução lenta. A evidência científica tem mostrado que os doentes com
Síndrome de Sjögren primária têm maior prevalência de diminuição da densidade
mineral óssea. Dessa forma, são doentes com maior probabilidade de desenvolverem
osteopenia e osteoporose e, consequentemente, maior risco de terem fraturas de
fragilidade.
Objetivos: Determinar a prevalência da diminuição da densidade mineral óssea nos
doentes diagnosticados com Síndrome de Sjögren primária, seguidos na consulta de
Reumatologia da Unidade Local de Saúde de Castelo Branco, e perceber se existe alguma
associação entre as características clínicas dos doentes com os fatores de risco
conhecidos para a osteopenia e osteoporose.
Métodos: Este estudo observacional e retrospetivo é composto por todos os doentes
com diagnóstico de Síndrome de Sjögren primária seguidos na consulta de Reumatologia
da Unidade Local de Saúde de Castelo Branco. A avaliação da densidade mineral óssea é
obtida através da realização da osteodensitometria, estando o diagnóstico de osteopenia
e osteoporose de acordo com os critérios da Organização Mundial da Saúde. É analisado
o perfil clínico da amostra e estudada a influência da idade atual, anos de duração da
doença, índice de massa corporal e toma de corticoides na perda de massa óssea, através
de uma regressão logística.
Resultados: O estudo incide num total de 38 doentes. O rácio entre mulheres e homens
é de 9:1. A média da idade da amostra é 60,82 anos. A média da duração da patologia é
de 4,76 anos. Os corticoides são usados com uma frequência de 70,3%. 57,9% dos
indivíduos têm excesso de peso ou obesidade. A prevalência da diminuição da densidade
mineral óssea é de 34,3%. Não foi encontrada associação estatisticamente significativa
(p-value>?) entre as variáveis consideradas e a densidade mineral óssea, pelo que, esta
não é influenciada pela idade atual, anos de duração da doença, índice de massa corporal
ou toma de corticoides.
Conclusão: Aproximadamente um terço dos doentes com Síndrome de Sjögren
primária tem diminuição da densidade mineral óssea. No entanto, esta não se associa
com a idade atual, os anos de duração da Síndrome de Sjögren primária, o índice de
massa corporal ou o uso de corticoides.
Introduction: Primary Sjögren's syndrome is a chronic and slowly progressive autoimmune disorder. Scientific evidence has shown that patients with primary Sjögren's Syndrome have a higher prevalence of reduced bone mineral density. Therefore, these patients are more likely to develop osteopenia and osteoporosis and, consequently, fragility fractures. Objectives: To determine the prevalence of reduced bone mineral density in patients diagnosed with primary Sjögren's Syndrome followed at the Rheumatology department of the Local Health Unit in Castelo Branco and investigate whether there is an association between patients’ clinical features with known risk factors for osteopenia and osteoporosis. Methods: This observational and retrospective investigation studied all patients diagnosed with primary Sjögren's Syndrome followed at the Rheumatology department of the Local Health Unit in Castelo Branco. Bone mineral density assessment was obtained by osteodensitometry and the diagnosis of osteopenia and osteoporosis was defined according to the World Health Organization criteria. Patients’ clinical profile is analyzed and it is investigated the influence of age, years of disease duration, body mass index and use of corticosteroids in bone loss, by logistic regression. Results: A total of 38 patients were enrolled in the study. Women to men ratio is 9:1. The mean age is 60,82 years. The mean duration of primary Sjögren's Syndrome is 4,76 years. Corticosteroids are used with a frequency of 70,3%. 57,9% of individuals are overweight or obese. The prevalence of reduced bone mineral density is 34,3%. No statistically significant association was found (p-value>?) between the considered variables and bone mineral density, meaning that it is not influenced by age, years of disease duration, body mass index or use of corticosteroids. Conclusion: Approximately one third of patients with primary Sjögren's Syndrome have reduced bone mineral density. This is not associated with age, years of duration of the primary Sjögren's syndrome, body mass index or use of corticosteroids.
Introduction: Primary Sjögren's syndrome is a chronic and slowly progressive autoimmune disorder. Scientific evidence has shown that patients with primary Sjögren's Syndrome have a higher prevalence of reduced bone mineral density. Therefore, these patients are more likely to develop osteopenia and osteoporosis and, consequently, fragility fractures. Objectives: To determine the prevalence of reduced bone mineral density in patients diagnosed with primary Sjögren's Syndrome followed at the Rheumatology department of the Local Health Unit in Castelo Branco and investigate whether there is an association between patients’ clinical features with known risk factors for osteopenia and osteoporosis. Methods: This observational and retrospective investigation studied all patients diagnosed with primary Sjögren's Syndrome followed at the Rheumatology department of the Local Health Unit in Castelo Branco. Bone mineral density assessment was obtained by osteodensitometry and the diagnosis of osteopenia and osteoporosis was defined according to the World Health Organization criteria. Patients’ clinical profile is analyzed and it is investigated the influence of age, years of disease duration, body mass index and use of corticosteroids in bone loss, by logistic regression. Results: A total of 38 patients were enrolled in the study. Women to men ratio is 9:1. The mean age is 60,82 years. The mean duration of primary Sjögren's Syndrome is 4,76 years. Corticosteroids are used with a frequency of 70,3%. 57,9% of individuals are overweight or obese. The prevalence of reduced bone mineral density is 34,3%. No statistically significant association was found (p-value>?) between the considered variables and bone mineral density, meaning that it is not influenced by age, years of disease duration, body mass index or use of corticosteroids. Conclusion: Approximately one third of patients with primary Sjögren's Syndrome have reduced bone mineral density. This is not associated with age, years of duration of the primary Sjögren's syndrome, body mass index or use of corticosteroids.
Description
Keywords
Densidade Mineral Óssea Osteopenia Osteoporose Reumatologia Síndrome de Sjögren