| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 933.28 KB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
A esclerose múltipla (EM) é uma doença crónica e imprevisível do sistema nervoso central que afecta mais de 1 milhão de pessoas em todo o mundo, das quais 5000 são portugueses. Foi reconhecida como uma doença há mais de 100 anos e é actualmente objecto de pesquisas intensas em relação às suas causas e tratamento. A diferente susceptibilidade à doença, a sua desigual distribuição geográfica e o facto de migrações de zonas de maior prevalência para zonas de menor prevalência nos primeiros anos de vida, diminuírem o risco de desenvolvimento de EM, parecem sugerir efectivamente uma interacção entre factores genéticos e ambientais. Com esta dissertação de mestrado pretende-se fazer uma revisão bibliográfica onde é exposta a doença com todo o seu perfil clínico; o tema central incide na abordagem aos factores etiológicos que condicionam o aparecimento da EM, com base numa bibliografia epidemiológica actualizada que documenta e analisa as variações da incidência e prevalência da doença segundo a localização geográfica e susceptibilidade genética, trajectos migratórios e infecções virais, entre outros factores. Por fim, um apontamento de considerações e perspectivas é feito com o objectivo prático e real de instituir um cunho de utilidade clínica, às evidências etiológicas aqui fundamentadas.
The multiple sclerosis (MS) is a chronic and unexpected central nervous system illness that affect more than 1 million of people in the whole world, of which 5000 are Portuguese. It was recognized as an illness has more than 100 years ago and its causes and treatment have been currently object of intense research. The different illness susceptibility, its different geographic distribution and the fact of migrations of zones of bigger prevalence for zones of lesser prevalence in the first years of life, diminish the risk of development of MS, seem to suggest an interaction between genetic and environmental factors. This Mastership Thesis intends to make bibliographic revision where the illness is described with all its clinical profile, and where the central subject is the etiologic factors that influence the appearance of MS, through an actual epidemiologic bibliography that justifies the illness incidence and prevalence by geographic localization and genetic predisposition, migrations and infections, among others factors. Finally, a conclusion and perspective note is made with the real and practic goal of institute a clinical utility profile, to the etiologic evidences.
The multiple sclerosis (MS) is a chronic and unexpected central nervous system illness that affect more than 1 million of people in the whole world, of which 5000 are Portuguese. It was recognized as an illness has more than 100 years ago and its causes and treatment have been currently object of intense research. The different illness susceptibility, its different geographic distribution and the fact of migrations of zones of bigger prevalence for zones of lesser prevalence in the first years of life, diminish the risk of development of MS, seem to suggest an interaction between genetic and environmental factors. This Mastership Thesis intends to make bibliographic revision where the illness is described with all its clinical profile, and where the central subject is the etiologic factors that influence the appearance of MS, through an actual epidemiologic bibliography that justifies the illness incidence and prevalence by geographic localization and genetic predisposition, migrations and infections, among others factors. Finally, a conclusion and perspective note is made with the real and practic goal of institute a clinical utility profile, to the etiologic evidences.
Description
Keywords
Esclerose múltipla Esclerose múltipla - Factores de risco Esclerose múltipla - Aspectos genéticos Esclerose múltipla - Agentes infecciosos Esclerose múltipla - Aspectos etiológicos Esclerose múltipla - Distribuição geográfica
Pedagogical Context
Citation
Publisher
Universidade da Beira Interior