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Abstract(s)
Introdução: Os sintomas neuropsiquiátricos são uma marca importante do Síndrome de Cushing, com repercussões significativas na qualidade de vida desses pacientes. O objetivo deste trabalho é avaliar a prevalência das manifestações psicológicas/psiquiátricas no Síndrome de Cushing e a sua evolução após correção do hipercortisolismo.
Metodologia: Recolha de artigos científicos com estudos nesta área e seleção da bibliografia mais relevante, utilizando os motores de busca PubMed e Google Académico.
Resultados: Em onze artigos, com um total de 654 doentes com Síndrome de Cushing, a prevalência dos distúrbios psiquiátricos foi de 40% a 86%. Existiu uma melhoria dos sintomas neuropsiquiátricos e da qualidade de vida global dos pacientes logo após a cura da doença de base, apesar de se notarem sintomas residuais a longo-prazo na maioria dos doentes.
Discussão e conclusão: O tratamento dirigido à disfunção endócrina de base é, numa primeira fase, suficiente para a melhoria dos sintomas neuropsiquiátricos. Contudo, deve continuar a dar-se atenção às manifestações que permanecem, as quais têm um impacto significativo na qualidade de vida dos pacientes, podendo ser necessário acompanhamento psicológico ou psiquiátrico e terapêutica psicotrópica.
Introduction: Neuropsychiatric symptoms are an important mark of Cushing’s syndrome, with significant impact on patient’s quality of life. The aim of this revision is to evaluate the evolution of psychological or psychiatric manifestations and quality of life of these patients after correction of hypercortisolism. Methods: Search of scientific articles with studies in this area, and selection of the most relevant ones, by using PubMed and Academic Google. Results: In eleven articles, with a total of 654 patients with Cushing’s syndrome, the prevalence of psychiatric disorders was between 40% and 86%. Following treatment of subjacent disease, there was an improvement of neuropsychiatric symptoms and global quality of life, although there were residual symptoms on a long-term basis in most of the patients. Discussion and Conclusion: The treatment directed to the endocrine dysfunction is initially enough to improve neuropsychiatric symptoms. However, care should be taken to observe residual symptoms, which have a significant impact on patient’s quality of life, and psychiatric or psychological support and psychotropic therapy may be necessary.
Introduction: Neuropsychiatric symptoms are an important mark of Cushing’s syndrome, with significant impact on patient’s quality of life. The aim of this revision is to evaluate the evolution of psychological or psychiatric manifestations and quality of life of these patients after correction of hypercortisolism. Methods: Search of scientific articles with studies in this area, and selection of the most relevant ones, by using PubMed and Academic Google. Results: In eleven articles, with a total of 654 patients with Cushing’s syndrome, the prevalence of psychiatric disorders was between 40% and 86%. Following treatment of subjacent disease, there was an improvement of neuropsychiatric symptoms and global quality of life, although there were residual symptoms on a long-term basis in most of the patients. Discussion and Conclusion: The treatment directed to the endocrine dysfunction is initially enough to improve neuropsychiatric symptoms. However, care should be taken to observe residual symptoms, which have a significant impact on patient’s quality of life, and psychiatric or psychological support and psychotropic therapy may be necessary.
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Keywords
Síndrome de Cushing Síndrome de Cushing - Hipercortisolémia Síndrome de Cushing - Aspectos neuropsiquiátricos Síndrome de Cushing - Aspectos cognitivos Síndrome de Cushing - Diagnóstico Síndrome de Cushing - Tratamento
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Universidade da Beira Interior