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Abstract(s)
O presente relatório de estágio está dividido em três capítulos, referentes à experiência profissionalizante nas vertentes de investigação, farmácia hospitalar e farmácia comunitária.
O primeiro capítulo, enquadrado na vertente de investigação, descreve as principais aplicações clínicas da insulina intranasal e as suas estratégias de formulação. Enquanto hormona, a insulina tem como função regular o metabolismo dos hidratos de carbono, sendo utilizada como agente terapêutico na diabetes mellitus. Dadas as características peptídicas que limitam a sua administração à via subcutânea, novas vias têm vindo a ser estudadas, surgindo um grande interesse pela via nasal. Neste sentido, com este trabalho pretende-se rever as várias aplicações da insulina por via nasal (efeito sistémico vs. efeito central) e analisar a sua eficácia, segurança e perspetiva de comercialização enquanto agente terapêutico. Constatou-se que a nível sistémico, a insulina é essencialmente utilizada para o tratamento da diabetes mellitus, tendo-se desenvolvido uma formulação com insulina humana recombinante adaptada à via intranasal, a NasulinTM. Com base em resultados pré-clínicos e clínicos, foi proposto que a doença de Alzheimer pode ser um alvo terapêutico para a insulina a nível central, havendo dados que apontam no sentido de melhoria no processo de memória e cognição.
O segundo capítulo, referente ao estágio em farmácia hospitalar, reflete as atividades desenvolvidas e os conhecimentos adquiridos durante o período de estágio no Centro Hospitalar Cova da Beira, no período de 26 de Janeiro a 20 de Março de 2015, num total de oito semanas.
O terceiro capítulo, incluído na experiência profissionalizante em farmácia comunitária, descreve as atividades desenvolvidas e os conhecimentos adquiridos durante o período de estágio na farmácia Sant’Ana, no período de 23 de março a 12 de junho de 2015, num total de doze semanas.
The present thesis is divided in three chapters which relate to professional experience in the areas of research, hospital and community pharmacy. The first chapter, related to the research area, describes the main clinical applications of intranasal insulin and their formulation strategies. As a hormone, insulin regulates the carbohydrates’ metabolism being therefore used as a therapeutic agent in diabetes mellitus. Taking into account the peptides’ characteristics, which limit their subcutaneous administration, new ways of administration have been studied, being the intranasal route the most promising one. The aims of this report were to review several applications of nasal insulin (systemic vs. central effects) and analyze their effectiveness, security and perspective of marketing as a therapeutic agent. Insulin is mainly used to treat diabetes mellitus, being developed an intranasal formulation with human recombinant insulin, NasulinTM. Based on pre clinic and clinic results, it has been theorized that the Alzheimer’s disease can be a target to insulin’s central action resulting in improvements in memory and cognitive processes. The second chapter, concerning to the hospital pharmacy internship, reflects the activities developed and the acquired knowledge during the internship in Hospital Centre of Cova da Beira, between January 26th and March 20th , 8 weeks in total. The third chapter, regarding the professional experience in community pharmacy, describes the activities developed and the acquired knowledge during the internship in Sant’Ana pharmacy, between March 23th and June 12th, 12 weeks in total.
The present thesis is divided in three chapters which relate to professional experience in the areas of research, hospital and community pharmacy. The first chapter, related to the research area, describes the main clinical applications of intranasal insulin and their formulation strategies. As a hormone, insulin regulates the carbohydrates’ metabolism being therefore used as a therapeutic agent in diabetes mellitus. Taking into account the peptides’ characteristics, which limit their subcutaneous administration, new ways of administration have been studied, being the intranasal route the most promising one. The aims of this report were to review several applications of nasal insulin (systemic vs. central effects) and analyze their effectiveness, security and perspective of marketing as a therapeutic agent. Insulin is mainly used to treat diabetes mellitus, being developed an intranasal formulation with human recombinant insulin, NasulinTM. Based on pre clinic and clinic results, it has been theorized that the Alzheimer’s disease can be a target to insulin’s central action resulting in improvements in memory and cognitive processes. The second chapter, concerning to the hospital pharmacy internship, reflects the activities developed and the acquired knowledge during the internship in Hospital Centre of Cova da Beira, between January 26th and March 20th , 8 weeks in total. The third chapter, regarding the professional experience in community pharmacy, describes the activities developed and the acquired knowledge during the internship in Sant’Ana pharmacy, between March 23th and June 12th, 12 weeks in total.
Description
Keywords
Aplicações Clínicas Estratégias de Formulação Farmácia Comunitária Farmácia Hospitalar Insulina Via Intranasal