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Authors
Abstract(s)
O presente trabalho encontra-se dividido em dois capítulos. O primeiro capítulo
intitula-se “Farmacovigilância na Beira Interior: resultados dos primeiros 4 anos de
atividade da Unidade de Farmacovigilância da Beira Interior”. O segundo capítulo
refere-se ao relatório de estágio curricular em Farmácia Comunitária.
O primeiro capítulo apresenta a análise das notificações espontâneas recebidas pela
Unidade de Farmacovigilância da Beira Interior desde o início da sua atividade, em
2017, até ao final de 2020. As notificações espontâneas foram classificadas tendo em
conta o tipo de notificador (utente ou profissional de saúde, neste caso médico,
enfermeiro, farmacêutico ou outro), o ano em que foram notificadas e o distrito onde
foram reportadas (Castelo Branco, Guarda ou Viseu). Relativamente à caracterização
demográfica do doente, os casos suspeitos foram agrupados em três faixas etárias e
classificados em termos de género. No que diz respeito à caracterização das reações
adversas a medicamentos, foi avaliada a gravidade, o critério de gravidade e foi
classificado o evento adverso. Foram, ainda, avaliados os graus de probabilidade dos
casos em que o critério de gravidade foi incapacidade, hospitalização, risco de vida ou
morte. As notificações que continham termos Important Medical Event/ Designated
Medical Event (IME/DME) foram analisadas e caracterizadas. Os medicamentos
suspeitos associados à ocorrência das reações adversas também foram investigados.
Neste período foram analisadas 644 notificações espontâneas. A população analisada
era constituída maioritariamente por utentes do sexo feminino (57%) e da faixa etária
dos 18-64 anos (49%). Os médicos foram os profissionais de saúde que submeteram
mais notificações (51%). A maior parte dos casos notificados foram classificados como
graves (52%). Os casos suspeitos de reação adversa a medicamentos que apresentavam
maior prevalência estavam inseridos no grupo de “Doenças gastrointestinais” (20%).
Relativamente à classe farmacoterapêutica, os antineoplásicos e imunomoduladores
foram os mais comumente reportados. Este estudo reforça a importância da
farmacovigilância e do seu contributo para o aumento do conhecimento do perfil de
segurança dos medicamentos.
No segundo capítulo estão descritas todas as atividades inerentes ao farmacêutico
comunitário desenvolvidas no decorrer do meu estágio curricular na Farmácia Avenida
na cidade do Fundão.
The present work is divided into two chapters. The first chapter is entitled “Pharmacovigilance in Beira Interior: results of the first four years of activity of the Beira Interior Pharmacovigilance Unit”. The second chapter refers to the curricular internship’s report that was held at a community pharmacy. The first chapter presents the analysis of spontaneous reports received by the Beira Interior Pharmacovigilance Unit since its inauguration until the end of 2020. Reports were classified according to type of notifier, the year in which it was notified and the district where it was reported (Castelo Branco, Guarda or Viseu). Regarding the patient’s demographic characterization, the suspected cases were grouped into three age categories and classified in terms of gender. As for the adverse drug reactions’ characterization, the severity and the severity criteria were evaluated, and the adverse event were classified. The degrees of probability of the cases in which the severity criteria were disability, hospitalisation, risk of death or death were also evaluated. Reports containing Important Medical Event/ Designated Medical Event (IME/DME) terms were analysed and characterised. The suspected drugs associated with the occurrence of adverse reactions were also investigated. In this period, 644 spontaneous reports were analysed. The population analysed consisted mostly of female users (57%) and people aged 18-64 years (49%). Physicians were the health professionals who submitted the most reports (51%). Most of the reported cases were classified as serious (52%). The suspected adverse drug reaction most frequently reported was within the category of gastrointestinal disorders (20%). The antineoplastic and immunomodulating drugs were the therapeutic agents most common involved. This study highlights the importance of pharmacovigilance and its contribution to increase the safety profile of the drugs’ knowledge. The second chapter describes all the activities concerning the community pharmacist’s activity developed during my curricular internship at Farmácia Avenida in Fundão.
The present work is divided into two chapters. The first chapter is entitled “Pharmacovigilance in Beira Interior: results of the first four years of activity of the Beira Interior Pharmacovigilance Unit”. The second chapter refers to the curricular internship’s report that was held at a community pharmacy. The first chapter presents the analysis of spontaneous reports received by the Beira Interior Pharmacovigilance Unit since its inauguration until the end of 2020. Reports were classified according to type of notifier, the year in which it was notified and the district where it was reported (Castelo Branco, Guarda or Viseu). Regarding the patient’s demographic characterization, the suspected cases were grouped into three age categories and classified in terms of gender. As for the adverse drug reactions’ characterization, the severity and the severity criteria were evaluated, and the adverse event were classified. The degrees of probability of the cases in which the severity criteria were disability, hospitalisation, risk of death or death were also evaluated. Reports containing Important Medical Event/ Designated Medical Event (IME/DME) terms were analysed and characterised. The suspected drugs associated with the occurrence of adverse reactions were also investigated. In this period, 644 spontaneous reports were analysed. The population analysed consisted mostly of female users (57%) and people aged 18-64 years (49%). Physicians were the health professionals who submitted the most reports (51%). Most of the reported cases were classified as serious (52%). The suspected adverse drug reaction most frequently reported was within the category of gastrointestinal disorders (20%). The antineoplastic and immunomodulating drugs were the therapeutic agents most common involved. This study highlights the importance of pharmacovigilance and its contribution to increase the safety profile of the drugs’ knowledge. The second chapter describes all the activities concerning the community pharmacist’s activity developed during my curricular internship at Farmácia Avenida in Fundão.
Description
Keywords
Beira Interior Farmácia Comunitária Farmacovigilância Notificações Espontâneas Reações Adversas a Medicamentos