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Efeitos do paracetamol na performance desportiva: Revisão sistemática e meta-análise
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Esta dissertação foi elaborada com vista à obtenção de grau de Mestre em Ciências Farmacêuticas, sendo parte integrante da Unidade Curricular de Estágio. Encontra-se dividida em três capítulos: o Capítulo I referente à componente de Investigação, o Capítulo II diz respeito ao relatório de estágio em Farmácia Hospitalar e o Capítulo III remete para o relatório de estágio em Farmácia Comunitária. O Capítulo I consiste numa revisão sistemática e meta-análise com vista a determinar se a ingestão aguda de paracetamol tem a capacidade de melhorar a performance física em indivíduos saudáveis atletas ou praticantes assíduos de diferentes modalidades. Os artigos foram pesquisados nas bases de dados Pubmed e Isi Web of Knowledge e a análise estatística foi realizada através do software R project. Foram incluídos 13 artigos que obedeceram aos critérios de inclusão e exclusão pré-definidos e foram analisadas 9 variáveis distintas: tempo para realização da tarefa em questão, mean power output, temperatura corporal, frequência cardíaca, perceção de dor, taxa de perceção de esforço, lactato sanguíneo, consumo máximo de oxigénio e total work. Os resultados obtidos sugeriram que o paracetamol proporcionou uma pequena, contudo estatisticamente significativa, melhoria no tempo para a realização da tarefa física (redução média de 0,50 segundos, intervalo de confiança 95% = [-0,96; -0,04]). Contudo, não apresentou efeitos estatisticamente significativos nas restantes variáveis. Quanto à modalidade desportiva, os resultados sugeriram que o efeito da administração do paracetamol poderá ser mais positivo em atividades que exijam esforços contínuos e cíclicos, como o ciclismo. Em suma, os resultados obtidos neste estudo não permitem considerar que o paracetamol tenha aumentado a performance física dos participantes em questão de forma significativa. O Capítulo II relata a experiência e conhecimentos adquiridos durante o período de estágio curricular nas instalações da Unidade Local de Saúde Cova da Beira no período de 30 de setembro a 22 de novembro de 2024, sob orientação da diretora dos Serviços Farmacêuticos, a Dra. Olímpia Fonseca. Ao longo das oito semanas de estágio na Farmácia Hospitalar tive a oportunidade de contactar com as diferentes áreas de atuação do farmacêutico e compreender a importância do seu papel no bem-estar do doente. O Capítulo III refere-se ao relatório de estágio curricular desenvolvido na Farmácia Pedroso, situada na Covilhã, no período compreendido entre 25 de novembro de 2024 e 14 de fevereiro de 2025, sob supervisão do Dr. João Vale. Nele estão descritas as atividades desenvolvidas e competências adquiridas ao longo desse período, destacando a missão crucial do farmacêutico para a sociedade, com especial destaque para a população envelhecida.
This dissertation was written with a view to obtaining a Master's degree in Pharmaceutical Sciences, and is an integral part of the Internship Curricular Unit. It is divided into three chapters: Chapter I refers to the Research component, Chapter II refers to the internship report in Hospital Pharmacy and Chapter III refers to the internship report in Community Pharmacy. Chapter I consists of a systematic review and meta-analysis to determine whether acute ingestion of paracetamol has the capacity to improve physical performance in healthy individuals who are athletes or regular practitioners of different sports. The articles were searched in the Pubmed and Isi Web of Knowledge databases and the statistical analysis was carried out using the R project software. Thirteen articles were included which met the pre-defined inclusion and exclusion criteria and 9 different variables were analyzed: time to perform the task in question, mean power output, body temperature, heart rate, pain perception, rate of perceived exertion, blood lactate, maximum oxygen consumption and total work. The results obtained suggested that paracetamol provided a small but statistically significant improvement in the time taken to perform the physical task (average reduction of 0.50 seconds, 95% confidence interval = [-0.96; -0.04]). However, there were no statistically significant effects on the other variables. As for the sport, the results suggest that the effect of paracetamol administration may be more positive in activities that require continuous and cyclical efforts, such as cycling. In short, the results obtained in this study do not suggest that paracetamol significantly increased the physical performance of the participants in question. Chapter II reports on the experience and knowledge acquired during my internship at the Cova da Beira Local Health Unit from September 30 to November 22, 2024, under the guidance of the Director of Pharmaceutical Services, Dr. Olímpia Fonseca. During my eightweek internship at the Hospital Pharmacy,I had the opportunity to get to know the different areas in which pharmacists work and understand the importance of their role in patient well-being. Chapter III refers to the curricular internship report developed at Farmácia Pedroso, located in Covilhã, between November 25, 2024 and February 14, 2025, under the supervision of Dr. João Vale. It describes the activities carried out and the skills acquired during this period, highlighting the crucial mission of the pharmacist for society, with special emphasis on the ageing population.
This dissertation was written with a view to obtaining a Master's degree in Pharmaceutical Sciences, and is an integral part of the Internship Curricular Unit. It is divided into three chapters: Chapter I refers to the Research component, Chapter II refers to the internship report in Hospital Pharmacy and Chapter III refers to the internship report in Community Pharmacy. Chapter I consists of a systematic review and meta-analysis to determine whether acute ingestion of paracetamol has the capacity to improve physical performance in healthy individuals who are athletes or regular practitioners of different sports. The articles were searched in the Pubmed and Isi Web of Knowledge databases and the statistical analysis was carried out using the R project software. Thirteen articles were included which met the pre-defined inclusion and exclusion criteria and 9 different variables were analyzed: time to perform the task in question, mean power output, body temperature, heart rate, pain perception, rate of perceived exertion, blood lactate, maximum oxygen consumption and total work. The results obtained suggested that paracetamol provided a small but statistically significant improvement in the time taken to perform the physical task (average reduction of 0.50 seconds, 95% confidence interval = [-0.96; -0.04]). However, there were no statistically significant effects on the other variables. As for the sport, the results suggest that the effect of paracetamol administration may be more positive in activities that require continuous and cyclical efforts, such as cycling. In short, the results obtained in this study do not suggest that paracetamol significantly increased the physical performance of the participants in question. Chapter II reports on the experience and knowledge acquired during my internship at the Cova da Beira Local Health Unit from September 30 to November 22, 2024, under the guidance of the Director of Pharmaceutical Services, Dr. Olímpia Fonseca. During my eightweek internship at the Hospital Pharmacy,I had the opportunity to get to know the different areas in which pharmacists work and understand the importance of their role in patient well-being. Chapter III refers to the curricular internship report developed at Farmácia Pedroso, located in Covilhã, between November 25, 2024 and February 14, 2025, under the supervision of Dr. João Vale. It describes the activities carried out and the skills acquired during this period, highlighting the crucial mission of the pharmacist for society, with special emphasis on the ageing population.
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Desporto Farmácia Comunitária Farmácia Hospitalar Paracetamol Performance Desportiva