| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 629.19 KB | Adobe PDF |
Authors
Abstract(s)
Introdução: Anorexia nervosa (AN) é uma doença do foro psiquiátrico que afeta
predominantemente o sexo feminino numa relação de 9 por cada 10 casos. Tendo em
conta a epidemiologia desta perturbação, que se inicia principalmente na adolescência,
torna-se essencial perceber, não só os efeitos nefastos imediatos, mas também os que
aportam consequências para a vida adulta. Face a esta problemática é de salientar que
a perda de densidade mineral óssea (DMO) é uma das consequências não reversíveis da
AN, sendo das mais impactantes por ocorrer logo na fase precoce da doença. Neste
sentido, é importante inferir os efeitos no metabolismo ósseo e o papel das hormonas
neste processo de modo a perceber quais os riscos futuros de alguém que padece desta
perturbação, possibilitando uma investigação e intervenção adequada e atempada.
Assim, este trabalho tem como objetivo realizar uma revisão bibliográfica sobre o
possível impacto da AN no metabolismo ósseo.
Metodologia: Através da base eletrónica PubMed/MEDLINE foi feita uma pesquisa e
selecionados artigos entre 2013 e 2023 em inglês. Os termos da pesquisa foram:
“anorexia” and “bone metabolism”. Os critérios de inclusão utilizados foram: artigos
em inglês; artigos originais; artigos publicados nos últimos 10 anos (entre 2013-2023);
população do estudo contendo indivíduos do sexo feminino com AN, sem serem
aplicadas restrições quanto à idade.
Os critérios de exclusão utilizados foram: artigos que incidem maioritariamente sobre
outras patologias que não a AN; artigos que incidiam maioritariamente sobre o
tratamento da AN; artigos sem acesso; artigos publicados fora do intervalo de pesquisa.
Adicionalmente, para a elaboração do tópico 5.4. “Importantes adaptações hormonais
na AN” foram também incluídos artigos de revisão, uma vez que, as informações
referentes a algumas hormonas já haviam sido amplamente discutidas.
Resultados e Conclusões: De uma forma geral, existe uma forte correlação entre a
AN e o metabolismo ósseo. Importa aprofundar os conhecimentos adquiridos até à data
relativamente a esta temática na tentativa de prevenir o impacto negativo da AN no
tecido ósseo. Note-se que os efeitos na DMO são uma das consequências não reversíveis
da AN, sendo das mais impactantes por ocorrer logo na fase precoce da doença.
Introduction: AN is a psychiatric disorder that predominantly affects females in a ratio of 9 out of every 10 cases. Considering the epidemiology of this disorder, which begins mainly in adolescence, it is essential to understand not only the immediate harmful effects, but also those that have consequences in adulthood. In light of this problem, it is known that the loss of bone mineral density (BMD) is one of the nonreversible consequences of AN, being one of the most impactful as it occurs at an early stage of the disease. In this sense, it is important to infer the effects of bone metabolism and the role of hormones in this process in order to understand the future risks of someone suffering from this condition enabling adequate and timely investigation and intervention. Therefore, this work aims to carry out a literature review on the possible impact of AN in bone metabolism. Material and methods: A research was carried out using the PubMed/MEDLINE electronic database and articles were selected between 2013 and 2023 in English. The search terms were: “anorexia” and “bone metabolism”. The inclusion criteria for this study were: articles in english; original articles; articles published in the last 10 years (between 2013-2023); study population containing female individuals with AN, without being applied age restrictions. The exclusion criteria were: articles that focused on pathologies other than AN; articles that focused mainly on AN treatment; articles without access; articles published outside search range. Additionally, for the elaboration of the topic 5.4. “Importantes adaptações hormonais na AN” review articles were also included, since the information regarding some hormones had already been widely discussed. Results/Conclusions: Generally, there is a strong correlation between AN and bone metabolism. It is important to deepen the knowledge acquired to date regarding this topic in an attempt to prevent the negative impact of AN in bone tissue. It should be noted that the effects on BMD are one of the non-reversible consequences of AN, being one of the most impactful as they occur at an early age of the disease.
Introduction: AN is a psychiatric disorder that predominantly affects females in a ratio of 9 out of every 10 cases. Considering the epidemiology of this disorder, which begins mainly in adolescence, it is essential to understand not only the immediate harmful effects, but also those that have consequences in adulthood. In light of this problem, it is known that the loss of bone mineral density (BMD) is one of the nonreversible consequences of AN, being one of the most impactful as it occurs at an early stage of the disease. In this sense, it is important to infer the effects of bone metabolism and the role of hormones in this process in order to understand the future risks of someone suffering from this condition enabling adequate and timely investigation and intervention. Therefore, this work aims to carry out a literature review on the possible impact of AN in bone metabolism. Material and methods: A research was carried out using the PubMed/MEDLINE electronic database and articles were selected between 2013 and 2023 in English. The search terms were: “anorexia” and “bone metabolism”. The inclusion criteria for this study were: articles in english; original articles; articles published in the last 10 years (between 2013-2023); study population containing female individuals with AN, without being applied age restrictions. The exclusion criteria were: articles that focused on pathologies other than AN; articles that focused mainly on AN treatment; articles without access; articles published outside search range. Additionally, for the elaboration of the topic 5.4. “Importantes adaptações hormonais na AN” review articles were also included, since the information regarding some hormones had already been widely discussed. Results/Conclusions: Generally, there is a strong correlation between AN and bone metabolism. It is important to deepen the knowledge acquired to date regarding this topic in an attempt to prevent the negative impact of AN in bone tissue. It should be noted that the effects on BMD are one of the non-reversible consequences of AN, being one of the most impactful as they occur at an early age of the disease.
Description
Keywords
Anorexia Nervosa Estradiol Fratura Metabolismo Osso Osteoporose