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Abstract(s)
Introdução: O papel da radioembolização (RE) em metástases hepáticas do carcinoma
colorretal (mhCCR) permanece indefinido. Esta investigação pretende avaliar os resultados
e possíveis fatores de prognóstico da RE nestes doentes.
Metodologia: Uma análise retrospetiva foi realizada a todos os doentes com mhCCR que
foram intervencionados com uma RE no Instituto Português de Oncologia do Porto, desde
janeiro de 2011 a março de 2020. A sobrevida a um ano foi determinada pelo método de
Kaplan-Meier e os possíveis fatores de prognóstico foram avaliados usando os testes logRank, Qui-quadrado, de Fisher, Mann-Whitney e teste-t para amostras independentes.
Resultados: Trinta pacientes foram avaliados. A idade média foi de 61,5 anos e a maioria
dos doentes eram do sexo masculino (63,3%). A dor abdominal foi a complicação mais
frequente (40%). O sucesso da RE foi observado em 50% dos casos. Um estádio inferior ou
igual a três, níveis inferiores a 20 ng/mL de CEA ao diagnóstico, um tempo livre de
metastização mais longo e a ausência de invasão vascular ou linfática ao diagnóstico estão
significativamente associados ao sucesso da RE (valores P de <0,001, 0,035, 0,036, 0,028
e 0,020, respetivamente). A sobrevida a um ano de pacientes com ou sem sucesso na RE foi
de 9,4 (IC 95%, 1,8-17,1) e 8,9 meses (IC 95%, 7,5-10,2), respetivamente.
Conclusão: Vários fatores aumentam a probabilidade de obter uma RE com sucesso. Foi
considerada uma terapêutica bem-tolerada, com a maioria das complicações facilmente
geridas. Ainda assim, são necessários mais estudos, com amostras maiores, para avaliar a
validade da RE.
Introduction: The role of radioembolization (RE) in liver dominant metastatic colorectal cancer (lmCRC) is unclear. This research aims to assess the prognostic factors and outcomes of RE in these patients. Methodology: A retrospective analysis of all patients with lmCRC who underwent RE in Instituto Português de Oncologia do Porto, from January 2011 to March 2020, was performed. The one-year survival was evaluated with the Kaplan-Meier method and potential prognostic factors were analyzed using the log-rank test, Mann-Whitney test, chisquare test, Fisher’s test, and t-test for independent samples. Results: Thirty patients were analyzed. The median age was 61,5 years and most patients were male (63,3%). There was a low complication rate. Successful RE was observed in 50% of the cases. Lower cancer stage, CEA levels at diagnosis lower than 20ng/mL, more than one year between diagnosis of CRC and the emergence of liver metastases, absence of vascular or lymphatic invasion at the moment of diagnosis were significantly associated with a successful RE (P values of <0,001, 0,035, 0,036, 0,028 and 0,020, respectively). The one-year survival of patients with and without successful RE was 9,4 months (CI 95%, 1,8- 17,1) and 8,9 months (CI 95%, 7,5-10,2), respectively. Conclusion: Several factors increase the likelihood of achieving a successful RE. The RE was considered a well-tolerated procedure, with easily managed complications and a low complication rate. However, more studies with larger cohorts are needed to validate this procedure.
Introduction: The role of radioembolization (RE) in liver dominant metastatic colorectal cancer (lmCRC) is unclear. This research aims to assess the prognostic factors and outcomes of RE in these patients. Methodology: A retrospective analysis of all patients with lmCRC who underwent RE in Instituto Português de Oncologia do Porto, from January 2011 to March 2020, was performed. The one-year survival was evaluated with the Kaplan-Meier method and potential prognostic factors were analyzed using the log-rank test, Mann-Whitney test, chisquare test, Fisher’s test, and t-test for independent samples. Results: Thirty patients were analyzed. The median age was 61,5 years and most patients were male (63,3%). There was a low complication rate. Successful RE was observed in 50% of the cases. Lower cancer stage, CEA levels at diagnosis lower than 20ng/mL, more than one year between diagnosis of CRC and the emergence of liver metastases, absence of vascular or lymphatic invasion at the moment of diagnosis were significantly associated with a successful RE (P values of <0,001, 0,035, 0,036, 0,028 and 0,020, respectively). The one-year survival of patients with and without successful RE was 9,4 months (CI 95%, 1,8- 17,1) and 8,9 months (CI 95%, 7,5-10,2), respectively. Conclusion: Several factors increase the likelihood of achieving a successful RE. The RE was considered a well-tolerated procedure, with easily managed complications and a low complication rate. However, more studies with larger cohorts are needed to validate this procedure.
Description
Keywords
Colorectal Cancer Liver Metastases Outcomes Prognostic Factors Radioembolization