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Abstract(s)
Introdução: As perturbações de ansiedade são das perturbações psiquiátricas mais comuns,
caracterizadas por medo excessivo, ansiedade e evitação de ameaças. São uma das principais
causas de incapacidade mundial, com uma prevalência cada vez maior. Está normalmente
associada a outras comorbilidades como depressão ou abuso de substâncias. A patogénese das
perturbações de ansiedade é complexa, envolvendo interações entre fatores biológicos,
influências do ambiente e mecanismos psicológicos.
Objetivos: Esta dissertação tem como objetivo reunir a literatura sobre o papel dos fatores
epigenéticos no desenvolvimento de perturbações de ansiedade.
Métodos: A pesquisa foi realizada na plataforma PubMed entre setembro de 2021 até abril de
2022.
Resultados: A análise da literatura sobre as influências da epigenética no desenvolvimento
de perturbações de ansiedade implica o envolvimento de genes que regulam o eixo hipotálamohipofise-adrenal, sistemas neurotransmissores ou plasticidade neuronal, e vários estudos
sugerem que a disrupção da expressão genética destes genes através de mecanismos de
epigenética contribuem para a patogénese de perturbações de ansiedade.
Conclusão: A investigação sobre qual a contribuição dos mecanismos epigenéticos para a
suscetibilidade ou resistência para o desenvolvimento das perturbações de ansiedade ainda se
encontra na sua infância pelo que será necessária mais pesquisa para clarificar detalhes nesta
área.
Introduction: Anxiety disorders are some of the most common psychiatric disorders. They’re characterized by excessive fear, anxiety, and threat avoidance. They’re one of the leading causes for disability worldwide, with a rising prevalence. It’s usually associated with comorbidities like depression and substance abuse. Anxiety disorder’s pathogenesis is complex, involving interactions between biology factors, environment influences and psychological mechanisms. Objectives: This dissertation aims to report on current literature findings about the role of epigenetic factors on the development of anxiety disorders. Methods: The research was done on the platform PubMed between the dates September 2021 until April 2022. Results: Current literature about epigenetics’ influence on the development of anxiety disorders implicates genes that regulate the axis hypothalamic-pituitary-adrenal, neurotransmitter systems, and neuroplasticity, and several studies suggest the disruption of the expression of these genes through epigenetic mechanisms contribute to the pathogenesis of AD. Conclusion: Research about the epigenetic mechanisms’ contribution towards susceptibility or resilience in developing anxiety disorders is still in its infancy and requires more more work to clarify details in the area.
Introduction: Anxiety disorders are some of the most common psychiatric disorders. They’re characterized by excessive fear, anxiety, and threat avoidance. They’re one of the leading causes for disability worldwide, with a rising prevalence. It’s usually associated with comorbidities like depression and substance abuse. Anxiety disorder’s pathogenesis is complex, involving interactions between biology factors, environment influences and psychological mechanisms. Objectives: This dissertation aims to report on current literature findings about the role of epigenetic factors on the development of anxiety disorders. Methods: The research was done on the platform PubMed between the dates September 2021 until April 2022. Results: Current literature about epigenetics’ influence on the development of anxiety disorders implicates genes that regulate the axis hypothalamic-pituitary-adrenal, neurotransmitter systems, and neuroplasticity, and several studies suggest the disruption of the expression of these genes through epigenetic mechanisms contribute to the pathogenesis of AD. Conclusion: Research about the epigenetic mechanisms’ contribution towards susceptibility or resilience in developing anxiety disorders is still in its infancy and requires more more work to clarify details in the area.
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Keywords
Ansiedade Epigenética Histonas Metilação Dna Rna Não Codificante