Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.6/4681
Título: Production of new 3D scaffolds for bone tissue regeneration by rapid prototyping
Autor: Fradique, Ricardo Gil
Correia, Tiago Ruivo
Miguel, Sónia Alexandra Pereira
Sá, Kevin Domingos de
Figueira, Daniela Sofia Rodrigues
Mendonça, António José Geraldes de
Correia, Ilídio Joaquim Sobreira
Palavras-chave: Alginate
Simulated Body Fluid
Bone Regeneration
Rapid Prototype
Composite Scaffold
Data: 17-Fev-2016
Editora: Springer
Citação: Fradique R., Correia, T.R., Miguel S.P., Sá K.D., Figueira D.R., Mendonça A.G. e Correia, I.J. (2016) "Production of new 3D scaffolds for bone tissue regeneration by rapid prototyping", Journal of Materials Science Materials in Medicine, Vol.27 (69)
Resumo: The incidence of bone disorders, whether due to trauma or pathology, has been trending upward with the aging of the worldwide population. The currently available treatments for bone injuries are rather limited, involving mainly bone grafts and implants. A particularly promising approach for bone regeneration uses rapid prototyping (RP) technologies to produce 3D scaffolds with highly controlled structure and orientation, based on computer-aided design models or medical data. Herein, tricalcium phosphate (TCP)/alginate scaffolds were produced using RP and subsequently their physicochemical, mechanical and biological properties were characterized. The results showed that 60/40 of TCP and alginate formulation was able to match the compression and present a similar Young modulus to that of trabecular bone while presenting an adequate biocompatibility. Moreover, the biomineralization ability, roughness and macro and microporosity of scaffolds allowed cell anchoring and proliferation at their surface, as well as cell migration to its interior, processes that are fundamental for osteointegration and bone regeneration.
Peer review: yes
URI: http://hdl.handle.net/10400.6/4681
DOI: 10.1007/s10856-016-5681-x
Versão do Editor: https://link.springer.com/article/10.1007%2Fs10856-016-5681-x#enumeration
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