Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.6/4690
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dc.contributor.authorCosta, Elisabete Cristina da Rocha-
dc.contributor.authorMoreira, André Ferreira-
dc.contributor.authorDiogo, Duarte Miguel de Melo-
dc.contributor.authorGaspar, Vítor Manuel Abreu-
dc.contributor.authorCarvalho, Marco António Paulo de-
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira-
dc.date.accessioned2018-03-21T15:40:51Z-
dc.date.available2018-03-21T15:40:51Z-
dc.date.issued2016-11-11-
dc.identifier.urihttp://hdl.handle.net/10400.6/4690-
dc.description.abstractIn comparison with 2D cell culture models, 3D spheroids are able to accurately mimic some features of solid tumors, such as their spatial architecture, physiological responses, secretion of soluble mediators, gene expression patterns and drug resistance mechanisms. These unique characteristics highlight the potential of 3D cellular aggregates to be used as in vitro models for screening new anticancer therapeutics, both at a small and large scale. Nevertheless, few reports have focused on describing the tools and techniques currently available to extract significant biological data from these models. Such information will be fundamental to drug and therapeutic discovery process using 3D cell culture models. The present review provides an overview of the techniques that can be employed to characterize and evaluate the efficacy of anticancer therapeutics in 3D tumor spheroids.pt_PT
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relationPOCI-01-0145-FEDER-007491pt_PT
dc.relationUID/Multi /00709/2013pt_PT
dc.relationSFRH/BD/103507/2014pt_PT
dc.relationSFRH/BD/109482/2015pt_PT
dc.relationSFRH/BD/103506/2014pt_PT
dc.rightsclosedAccesspt_PT
dc.subject3D tumor spheroidspt_PT
dc.subjectCancer therapypt_PT
dc.subjectIn vitro modelspt_PT
dc.subjectMethodologiespt_PT
dc.subjectTherapeutic screeningpt_PT
dc.title3D tumor spheroids: an overview on the tools and techniques used for their analysispt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
degois.publication.firstPage1427pt_PT
degois.publication.lastPage1441pt_PT
degois.publication.titleBiotechnology Advancespt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0734975016301379pt_PT
dc.peerreviewedyespt_PT
degois.publication.volume34pt_PT
dc.identifier.doi10.1016/j.biotechadv.2016.11.002pt_PT
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