Browsing by Author "Rodrigues, Miguel"
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- Characterization of the Mechanical and Biological Properties of a New Alumina ScaffoldPublication . Batista, Patrícia Sofia Pinhanços; Rodrigues, Miguel; Silva, Daniela; Morgado, Patrícia I.; Henriques, J.; Almeida, Maria; Silva, Abílio P.; Correia, Ilídio Joaquim SobreiraPurpose: In this work, an alumina scaffold was produced through a new method to be used in a near future as a bone substitute. Methods: In vitro and in vivo studies were performed in order to characterize the mechanical and biological properties of the scaffold. Results: the results obtained showed that this scaffold has high mechanical resistance and a porous surface that allows human osteoblast cells to adhere and proliferate. the in vivo studies revealed no systemic reaction. Conclusions: the alumina scaffold produced herein has the mechanical and biological properties that are compatible with its application in bone therapy.
- Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applicationsPublication . Coimbra, Patrícia; Ferreira, Paula; Sousa, Hermínio C. de; Batista, Patrícia Sofia Pinhanços; Rodrigues, Miguel; Correia, Ilídio Joaquim Sobreira; Gil, MariaIn this work, porous scaffolds obtained from the freeze-drying of pectin/chitosan polyelectrolyte complexes were prepared and characterized by FTIR, SEM and weight loss studies. Additionally, the cytotoxicity of the prepared scaffolds was evaluated in vitro, using human osteoblast cells. The results obtained showed that cells adhered to scaffolds and proliferated. The study also confirmed that the degradation by-products of pectin/chitosan scaffold are noncytotoxic.