Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications

Coimbra, Patrícia; Ferreira, Paula; Sousa, Hermínio C. de; Batista, Patrícia Sofia Pinhanços; Rodrigues, Miguel; Correia, Ilídio Joaquim Sobreira; Gil, Maria

http://hdl.handle.net/10400.6/4627

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Authors

Coimbra, Patrícia

Ferreira, Paula

Sousa, Hermínio C. de

Batista, Patrícia Sofia Pinhanços

Rodrigues, Miguel

Correia, Ilídio Joaquim Sobreira

Gil, Maria

Abstract(s)

In this work, porous scaffolds obtained from the freeze-drying of pectin/chitosan polyelectrolyte complexes were prepared and characterized by FTIR, SEM and weight loss studies. Additionally, the cytotoxicity of the prepared scaffolds was evaluated in vitro, using human osteoblast cells. The results obtained showed that cells adhered to scaffolds and proliferated. The study also confirmed that the degradation by-products of pectin/chitosan scaffold are noncytotoxic.

Keywords

Polymeric scaffold Polyelectrolyte complexes Cytotoxicity Osteoblasts

URI

http://hdl.handle.net/10400.6/4627

Citation

Coimbra, P., Ferreira, P., Sousa, H.C., Batista, P., Rodrigues, M.A., Correia, I.J. e Gil, M. H. (2011) “Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications”, International Journal of Biological Macromolecules, Vol. 48 (1), pp. 112-118