Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.6/4688
Título: Production and characterization of polycaprolactone- hyaluronic acid/chitosan-zein electrospun bilayer nanofibrous membrane for tissue regeneration
Autor: Figueira, Daniela Sofia Rodrigues
Miguel, Sónia Alexandra Pereira
Sá, Kevin Domingos de
Correia, Ilídio Joaquim Sobreira
Palavras-chave: Bilayer membrane
Human fibroblast cells
Wound healing
Data: 22-Set-2016
Citação: Figueira, D. R., Miguel, S. P., de Sá, K. D., e Correia, I. J. (2016) “Production and characterization of polycaprolactone-hyaluronic acid/chitosan-zein electrospun bilayer nanofibrous membrane for tissue regeneration.” International Journal of Biological Macromolecules, Vol.93 (Part A), pp.1100-1110
Resumo: A bilayered electrospun membrane was produced in this study, using the electrospinning technique, to be applied as a skin substitute. The upper layer of the membrane was comprised by hyaluronic acid and polycaprolactone in order to provide mechanical support and also to act as a physical barrier against external threats. Chitosan and zein were used to produce the bottom layer that was loaded with salicylic acid, in order to confer anti-inflammatory and antimicrobial activity to this layer. The physicochemical properties of the membranes were determined and the obtained results showed that the produced electrospun membrane display an ideal porosity, appropriate mechanical properties, controlled water loss and a suitable salicylic acid release profile. In addition, membranes did not exhibit any toxic effects for human fibroblast cells, since cells were able to adhere, spread and proliferate. Furthermore, no biofilm formation was noticed on membranes’ surface along the experiments. In conclusion, the gathered data reveal that this electrospun membrane has suitable properties to be used as a wound dressing.
Peer review: yes
URI: http://hdl.handle.net/10400.6/4688
DOI: 10.1016/j.ijbiomac.2016.09.080
Versão do Editor: https://www.sciencedirect.com/science/article/pii/S0141813016309382?via%3Dihub
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