FCS - DCM | Dissertações de Mestrado e Teses de Doutoramento
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Browsing FCS - DCM | Dissertações de Mestrado e Teses de Doutoramento by Author "Abreu, Antonio Alejandro Villasana de"
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- ExhaustedPublication . Abreu, Antonio Alejandro Villasana de; Patto, Maria da Assunção Morais e Cunha Vaz; Pinto, Nuno Filipe Cardoso; Gama, Jorge Manuel ReisIntroduction: Fatigue is a symptom described as the lack of energy and exhaustion and can be physical or cognitive. Currently, its measurement depends exclusively on subjective perception scales. Transcranial magnetic stimulation and the theta burst stimulation protocol (cTBS) appears as a non-invasive method used to explore and modulate brain functioning, may influence cognitive processing. Therefore, this investigation has as objective the study and quantification of different biological parameters that may be associated with fatigue and evaluate the different effects of cTBS in fatigue individuals. Methods and materials: A “crossover” study was carried out with 7 healthy adult volunteers (6 females and 1 male). In test A was proceeded to the realization of moderate aerobic exercise and reduction of sleep by 20% of the usual amount, and in test B was not proceeded to lifestyle changes. The fatigue was measured using Chalder scale and were performed verbal fluency test, visual reaction test, measurement of cerebral oximetry and evaluation of evoked cognitive potentials (P300), before and after the application of cTBS. It was proceeded to a follow-up of 4 weeks of the fatigue perception. For statistical analysis, the Friedman test was used and, when significant at 5%, pairwise comparisons were obtained with the Dunn test with Bonferroni correction. Correlations were measured using Spearman's correlation coefficient. Results: As expected, on test A, volunteers were considered fatigued according to chalder scale, but in test B they were not; however, the difference was statistically non-significant. In the verbal fluency test, both A and B groups shown better performance after cTBS, with no significant difference between them. cTBS slowed P300 latency, potentially more pronounced on the test A group. Conclusion: Despite a possible difference between groups A and B in P300 results after cTBS in the fatigued group, this was not significant. Therefore, in the present study it was not possible to conclude that fatigue can be measured objectively. Several limiting factors, namely the number of subjects, may have contributed to this.