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Authors
Alves, Patrícia
Correia, Ilídio Joaquim Sobreira
Ferreira, Paula
Advisor(s)
Abstract(s)
In the present study, small-sized porous scaffolds were obtained from the freeze-drying of sodium
hyaluronate/chitosan polyelectrolyte complexes. The obtained materials were characterized by a set of
techniques including attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy,
swelling determination and weight loss studies. The morphology of the scaffolds was observed using
scanning electron microscopy. Thermal characterization ofthe scaffolds was also performed by dynamic
mechanical thermal analysis and thermogravimetric analysis. Finally, the cytotoxic profile of the prepared scaffolds was evaluated in vitro, using mesenchymal stem cells. The results obtained showed that
cells adhered to scaffolds and proliferated. This study also confirmed that the degradation by-products of
sodium hyaluronate/chitosan scaffold are noncytotoxic, which is fundamental for its application in the
biomedical field.
Description
Keywords
Tissue engineering Polyelectrolyte complexes Polymeric scaffolds Cytotoxicity
Citation
Coimbra, P., Alves, P., Valente, T.A.M., Santos, R., Correia, I.J. e Ferreira, P. (2011) “Sodium hyaluronate/chitosan polyelectrolyte complex scaffolds for dental pulp regeneration: synthesis and characterization”, International Journal of Biological Macromolecules, Vol. 49(4), pp. 573-579
Publisher
Elsevier