Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.6/4706
Título: Coaxial electrospun PCL/Gelatin-MA fibers as scaffolds for vascular tissue engineering
Autor: Coimbra, Patrícia Manuela Almeida
Santos, Patrícia
Alves, Patrícia de Jesus Pinto
Miguel, Sónia Alexandra Pereira
Carvalho, Marco António Paulo de
Sá, Kevin Domingos de
Correia, Ilídio Joaquim Sobreira
Ferreira, Paula Cristina Nunes
Palavras-chave: Coaxial electrospinning
Photocrosslinking
Scaffolds
Tissue engineering
Biocompatibility
Data: 26-Jul-2017
Editora: Elsevier
Citação: 2.2.4.88. Coimbra, P., Santos, P., Alves, P., Miguel, S. P., Carvalho, M. P., de Sá, K. D., Correia, I. J. e Ferreira, P. (2017). “Coaxial electrospun PCL/Gelatin-MA fibers as scaffolds for vascular tissue engineering.” Colloids and Surfaces B: Biointerfaces, Vol. 159, pp.7-15.
Resumo: Coaxial electrospinning is a technique that allows the production of nanofibers with a core–shell structure. Such fibers present several advantages as materials for the preparation of scaffolds, namely due to the possibility of combining a core with the desired mechanical properties with a shell prepared from biocompatible materials that will establish proper interactions with the host. Herein, core-shell fibrous meshes, composed of a polycaprolactone (PCL) core and a functionalized gelatin shell, were prepared by coaxial electrospinning and then photocrosslinked under UV light aiming to be used in vascular tissue regeneration. The suitability of the meshes for the pretended biomedical application was evaluated by assessing their chemical/physical properties as well as their haemo and biocompatibility in vitro. The obtained results revealed that meshes’ shell prepared with a higher content of gelatin showed fibers with diameters presenting a unimodal distribution and a mean value of 600 nm. Moreover, those fibers with higher content of gelatin also displayed lower water contact angles, and therefore higher hydrophilicities. Such features are crucial for the good biologic performance displayed by these meshes, when in contact with blood and with Normal Human Dermal Fibroblasts cells.
Peer review: yes
URI: http://hdl.handle.net/10400.6/4706
DOI: 10.1016/j.colsurfb.2017.07.065
Versão do Editor: https://www.sciencedirect.com/science/article/pii/S0927776517304885#!
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